Pathway-based polygene risk for severe depression implicates drug metabolism in CONVERGE
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Improved Antidepressant Remission in Major Depression via a Pharmacokinetic Pathway Polygene Pharmacogenetic Report
OBJECTIVE Major depressive disorder (MDD) is projected to be a leading cause of disability globally by 2030. Only a minority of patients remit with antidepressants. If assay of polymorphisms influencing central nervous system (CNS) bioavailability could guide prescribers to more effectively dose patients, remission rates may improve and the burden of disease from MDD reduce. Hepatic and blood b...
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ژورنال
عنوان ژورنال: Psychological Medicine
سال: 2019
ISSN: 0033-2917,1469-8978
DOI: 10.1017/s0033291719000618